Bitter berry of hypertension

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Bitter berry and their potential role in the treatment of hypertension: A scientific review of theIntroductionThe term Bitter berry is used in folk medicine for plants with cardiac glycoside-containing substances, including, in particular, the Oleander (Nerium oleander). Despite its historical use in the treatment of cardiovascular diseases, including high blood pressure (arterial hypertension), is rejected, the application of this Plant due to its high toxicity in the modern medicine strictly. This article examines the chemical properties, the pharmacological effect, as well as the risks associated with the use of Oleander in hypertension.Chemical CompositionOleander contains a group of cardiac glycosides, including Oleandrin, Neriosid and Digitoxigenin. These substances act on the circulatory apparatus, by the activity of Na⁺/K⁺‑ATPase to inhibit the pump. This leads to an increased intracellular concentration of calcium ions (Ca2+) in Cardiomyocytes, which in turn strengthens the heart contraction (positive Inotrope).Pharmacological effect in hypertensionTheoretically, the heart could Glycosides strength properties of Oleander in heart failure and associated changes in blood pressure may be of Use. However:The effect on blood pressure is not directly lowering, but is the result of improved cardiac performance.In the case of primary arterial hypertension, increased heart contraction plays a therapeutic role.The substances can lead to the vasoconstrictive effects, which can increase blood pressure even.Toxicity and risksThe glycosides of oleanders are extremely toxic. Already small amounts (about 0.5 g of dried leaf) can lead to severe poisoning. Symptoms of oleander poisoning include:Cardiac arrhythmias (bradycardia, tachycardia, AV blocks)Nausea, Vomiting, DiarrheaDizziness, Blurred VisionIn severe case, circulatory collapse, and deathClinical evaluation and modern medicineIn modern evidence-based medicine Oleander is used in diseases for the treatment of high blood pressure or other cardiovascular disease. The therapeutic range (the difference between effective and lethal dose) is extremely small. Even in the case of the historical application of digitalis glycosides (from Foxglove) in heart failure with strict blood to be carried out in concentration checks. For Oleander such a safe and secure application guidelines do not exist.ConclusionAlthough the Bitter berry, in particular, Oleander, has substances with a significant effect on the cardiovascular System, is not justified their use for the treatment of hypertension scientific and life-threatening. The high toxicity outweighs any potential therapeutic Benefit in this indication. Patients with hypertension should only take proven effective and safe medicines that are prescribed by a doctor. The use of herbal products with unknown ingredients or proven toxicity is always refuse.Glossary Of Terms (Short Notes):Arterial Hypertension — High Blood PressureCardiac glycosides — substances which the force of the contraction of the heart muscle increaseInotrope — force of cardiac contractionVasoconstriction — narrowing of the blood vesselsTherapeutic range — difference between the minimum effective and toxic dose

Nililinis ang mga ugat na kailangang alagaan mula sa deposito at pinananatili ang kinakailangang lakas ng tibok ng puso! Bitter berry of hypertension. Ang mga tableta para pababain ang presyon ng dugo ay natural na nakakatulong para mabilis itong bumalik sa normal, pero inirerekomenda rin na baguhin ang pamumuhay. Ang malusog na pagkain, kontrol sa timbang, regular na ehersisyo, at pag-iwas sa paninigarilyo at alak ay magagandang paraan para maiwasan ang mataas na presyon ng dugo. Siguraduhing mas kaunting sodium (hal. asin) at mas maraming potassium (mga saging, spinach, broccoli) ang mapapasok sa katawan.

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